Dosage of Pyramax 180mg/60mg: Take as directed by the pharmacist or physician. The dosage is strictly based on the patient's body weight.

Administration: Swallow the film-coated tablets whole.

Best Time to Take It: Pyramax tablets can be taken with or without food. This is a key advantage as it simplifies the dosing regimen and aids patient compliance.

Dosing Schedule (General Adult/Weight greater than 20 kg): The full course is once daily for 3 consecutive days. The number of tablets (180mg/60mg) per day depends on the patient's body weight:

• For patients weighing 20 kg to under 24 kg: 1 tablet daily for 3 days.
• For patients weighing 24 kg to under 45 kg: 2 tablets daily for 3 days.
• For patients weighing 45 kg to under 65 kg: 3 tablets daily for 3 days.
• For patients weighing 65 kg or more: 4 tablets daily for 3 days.

Contraindications of Pyramax 180mg/60mg: Do NOT take Pyramax if you:

• Are allergic to pyronaridine, artesunate, or any component of the tablet.
• Have a known severe liver disease (e.g., decompensated cirrhosis) or clinical signs/symptoms of hepatic injury.
• Have severe renal impairment.
• Are taking concomitant medications that are known to significantly prolong the QTc interval or affect heart rhythm (e.g., certain antiarrhythmics or neuroleptics).

Side Effects of Pyramax:

• Common Side Effects (Expected): Headache, vomiting, eosinophilia, and transient increases in liver enzymes (liver transaminases).
• Serious but Rare Side Effects: Signs of severe liver injury (e.g., persistent nausea, abdominal pain, or jaundice).
• Monitoring Note: Due to the risk of liver toxicity (transient liver enzyme increases), liver function tests should be performed before and after the treatment course in some settings.

Precautions and Warnings of Pyramax:

• Severe Malaria: Pyramax is not for the treatment of severe or complicated malaria (e.g., cerebral malaria, severe anemia, renal failure).
• Other Medications: Inform your doctor about all other medications you are taking, especially those that affect the liver's metabolism (CYP2D6 inhibitors) or heart rhythm, to prevent drug interactions.
• Recurrent Infection: If malaria recurs within 28 days of treatment, a different antimalarial drug should be used.

Pregnancy & Breastfeeding: Should generally be avoided in the first trimester of pregnancy. Consult your doctor immediately if you are pregnant, planning to be pregnant, or breastfeeding.

Pack Size: Pyramax 180 mg/60 mg Film-coated tablets are supplied in blister packs.