About this item

Coveram Plus 5mg/1.25mg/10mg is a powerful triple-combination medication for managing high blood pressure (hypertension). 

Uses of Coveram Plus 5mg/1.25mg/10mg

Coveram Plus 5mg/1.25mg/10mg is prescribed primarily for the treatment of:

• Hypertension (high blood pressure) – Helps lower blood pressure and reduces the risk of heart disease, stroke, and kidney complications.
• Cardiovascular Protection – Reduces strain on the heart and improves circulation.
• Edema Management – Addresses fluid retention associated with hypertension.
• Secondary Uses – In some cases, physicians may prescribe Coveram Plus for off-label benefits, such as preventing angina (chest pain) and improving heart function.

Active Ingredients in Coveram Plus 5mg/1.25mg/10mg

Coveram Plus 5mg/1.25mg/10mg contains three key active ingredients:

1. Perindopril Arginine (5mg) – An ACE inhibitor that relaxes blood vessels, reducing blood pressure and improving heart function.
2. Indapamide (1.25mg) – A thiazide-like diuretic that helps remove excess sodium and water, reducing fluid retention and lowering blood pressure.
3. Amlodipine (10mg) – A calcium channel blocker that relaxes and widens blood vessels, ensuring smoother blood flow and reducing strain on the heart.

Contraindications of Coveram Plus 5mg/1.25mg/10mg

Coveram Plus should not be used by individuals who:

• Have a history of severe kidney or liver disease
• Are allergic to perindopril, indapamide, amlodipine, or any other ACE inhibitors or diuretics
• Have a history of angioedema (swelling of the face, throat, or tongue)
• Are pregnant or breastfeeding
• Have low potassium levels or high calcium levels
• Are taking certain medications, such as lithium or potassium-sparing diuretics, without medical supervision

Side Effects of Coveram Plus 5mg/1.25mg/10mg

Common Side Effects:

• Dizziness or lightheadedness
• Fatigue
• Swelling of the ankles (edema)
• Dry cough
• Headache
• Increased urination

Serious but Rare Side Effects:

• Severe allergic reactions (rash, difficulty breathing, swelling)
• Low blood pressure (hypotension)
• Irregular heartbeat
• Severe dizziness or fainting
• Kidney dysfunction

What to Do If Side Effects Occur:

• Mild side effects usually resolve over time. If symptoms persist, consult your doctor.
• Seek emergency medical attention for serious adverse reactions.

Precautions and Warnings of Coveram Plus 5mg/1.25mg/10mg

• Before starting Coveram Plus – A medical consultation is necessary, especially for individuals with existing kidney or liver conditions.
• During use – Avoid excessive salt intake and alcohol.
• Long-term safety considerations – Regular kidney function and electrolyte level checks are recommended.
  
  

• How Coveram Plus 5mg/1.25mg/10mg Works

• Each component of Coveram Plus works together to reduce blood pressure:
  • Perindopril inhibits an enzyme that constricts blood vessels.
  • Indapamide removes excess fluid, reducing blood volume.
  • Amlodipine relaxes and widens blood vessels for better circulation.

• Mode of Action of Coveram Plus 5mg/1.25mg/10mg

  • Lowers resistance in blood vessels.
  • Enhances blood flow by preventing narrowing of arteries.
  • Reduces strain on the heart, improving cardiovascular function.

• Interactions of Coveram Plus 5mg/1.25mg/10mg

• Drug Interactions:

  • Avoid combining with NSAIDs (ibuprofen, naproxen), as they may reduce effectiveness.
  • Lithium levels may increase when taken together, leading to toxicity.
  • Potassium supplements may cause dangerously high potassium levels.

• Food Interactions:

  • Grapefruit may enhance drug absorption, leading to potential side effects.

• Alcohol and Smoking:

  • Alcohol may enhance dizziness and hypotension.
  • Smoking reduces the effectiveness of blood pressure medications.

• Additional Information about Coveram Plus 5mg/1.25mg/10mg

  • Unique Fact: Coveram Plus is a triple-combination therapy that simplifies treatment by reducing the need for multiple medications.
  • Allergy Information: Contains lactose—consult your doctor if lactose intolerant.